Early detection and use of appropriate prognostic models may alleviate mortality and morbidity in paitents with ACLF. Grade-II and III MELD scores also contributed to the 30-day mortality with twenty three patients (28.8%) and nineteen patients (23.8%) dying within 30 days of admission (p<0.001).Ĭonclusion: MELD scores are able to accurately predict the short-term mortality in patients with ACLF and viral hepatitis was the most common etiology in our population. Eighty patients (43.2%) died within 30 days of admission.The 30-day mortality with respect to MELD grade was statistically significant (p<0.001) with the highest mortality noted in grade-IV and thirty five patients (43.8%) dying within 30 days of admission (p<0.001). One hundred and thirty patients (70.3%) had underlying viral hepatitis while twelve patients (6.5%) and forty three patients (23.2%) presented with alcoholic liver disease and drug-induced ACLF, respectively. Results: Majority of the enrolled patients were male (74.6%) while only 25.4% of the patients were female. Post-stratification chi-square test was calculated using 95% significance (p≤0.05). Data was stratified for age, gender, duration of chronic liver disease and MELD grade to address the effect modifiers. gender, etiology of acute-on-chronic liver failure and 30-day mortality were presented by frequency and percentage. Numerical variables including age was presented by Mean ± S.D. Data was entered and analyzed with SPSS version 23.0. One hundred and eighty five patients who met the inclusion criteria were enrolled using 95% confidence level and 4% margin of error. Methodology: This was a descriptive case series, conducted at Sheikh Zayed Hospital, Lahore, Pakistan from Januto July 30, 2018. Adult patients awaiting liver transplantation. We carried out this study to identity the 30-day mortality and etiology of patients presenting with ACLF using Model for End-Stage Liver Disease (MELD) score predictability. The new MELD scores are calculated first by determining the traditional MELD score as an initial score. Viral hepatitis is the most common cause of liver failure in our local population. In 2006, the probability of receiving a liver transplant increased from 18.5 for a patient with a MELD score from 10 to 19 to 58.4 for a patient with a MELD score from 20 to 29 and to 70.4 for. Acute on chronic liver failure (ACLF) has a high short term mortality rate. Background: Cirrhosis is a pathological condition that ultimately leads to liver failure.
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